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Efficacy, safety, and tolerability of ulotaront (SEP-363856, a trace amine-associated receptor 1 agonist) for the treatment of schizophrenia and other mental disorders: a systematic review of preclinical and clinical trials by Gia Han Le; Emily S. Gillissie; Taeho Greg Rhee; Bing Cao; Yazen Alnefeesi; Ziji Guo; Joshua D. Di Vincenzo; Muhammad Youshay Jawad; Andrew M. March; Ranuk Ramachandra; Leanna M.W. Lui; Roger S. McIntyre is a Medicine article available to read on EtoBox.

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Introduction: Schizophrenia is a mental illness that can disrupt emotions, perceptions, and cognition and reduce quality of life. The classical approach to treat schizophrenia is to use typical and atypical antipsychotics; however, limitations include low efficacy in mitigating negative symptoms and cognitive dysfunctions and a range of adverse effects. Evidence has accumulated on trace amine-associated receptor 1 (TAAR1) as a novel therapeutic target for treating schizophrenia. This systematic review investigates the available evidence on a TAAR1 agonist, ulotaront, as a treatment for schizophrenia. Methods: A systematic search was conducted on PubMed/MEDLINE and Ovid databases for Englishpublished articles from inception to 18 December 2022. The literature focusing on the association between ulotaront and schizophrenia was evaluated based on an inclusion/exclusion criterion. Selected studies were assessed for the risk of bias, using the Cochrane Collaboration tool, and summarized in a table to generate discussion topics. Results: Three clinical, two comparative, and five preclinical studies examining ulotaront's pharmacology, tolerability and safety, and/or efficacy were identifi

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Author

Gia Han Le; Emily S. Gillissie; Taeho Greg Rhee; Bing Cao; Yazen Alnefeesi; Ziji Guo; Joshua D. Di Vincenzo; Muhammad Youshay Jawad; Andrew M. March; Ranuk Ramachandra; Leanna M.W. Lui; Roger S. McIntyre

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Medicine (Health Sciences)