Can I read κ light chain — myeloma associated with adult Fanconi syndrome: Response of the nephropathy to treatment of myeloma on EtoBox?

κ light chain — myeloma associated with adult Fanconi syndrome: Response of the nephropathy to treatment of myeloma by Salman Gailani; Byeong‐Kuk Seon; Edward S. Henderson is a Medicine article available to read on EtoBox.

What is κ light chain — myeloma associated with adult Fanconi syndrome: Response of the nephropathy to treatment of myeloma about?

## Abstract The association of Bence Jones proteinuria with adult Fanconi syndrome has been reported in a small number of patients. The nephropathy and the Bence Jones proteinuria often precede by several years the diagnosis of frank myeloma. A 39‐year‐old woman developed renal glucosuria 2.5 years prior to the diagnosis of a plasma cell disease characterized by __k__ Bence Jones proteinuria, osteolytic lesions, and histologically proven plasmacytomas. Serum phosphorus of 1.1–2.1 mg/dl and uric acid of 1.3–1.6 mg/dl were compatible with Fanconi syndrome. Glucosuria was constantly present, while the glucose tolerance test was normal. Urinary β~2~ microglobulin (β~2~M) excretion was up to 135 mg/24 hours (normal less than 0.14 mg), indicating failure of tubular absorption of this protein. Amino‐aciduria was noted. The patient's myeloma responded to irradiation followed by melphalan plus prednisone and vincristine; the result was a marked reduction of the Bence Jones proteinuria. Some of the manifestations of the Fanconi syndrome disappeared, while the others were markedly reduced; this included disappearance of the glucosuria, elevation of the serum phosphorus and uric acid to normal

Who reads κ light chain — myeloma associated with adult Fanconi syndrome: Response of the nephropathy to treatment of myeloma?

Author

Salman Gailani; Byeong‐Kuk Seon; Edward S. Henderson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

1978

Language

EN

Field

Medicine (Health Sciences)