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High Prevalence of Radiological Vertebral Fractures in Women with Prolactin-secreting Pituitary Adenomas by Gherardo Mazziotti; Tatiana Mancini; Marilda Mormando; Ernesto De Menis; Antonio Bianchi; Mauro Doga; Teresa Porcelli; Pier Paolo Vescovi; Laura De Marinis; Andrea Giustina is a Medicine article available to read on EtoBox.
What is High Prevalence of Radiological Vertebral Fractures in Women with Prolactin-secreting Pituitary Adenomas about?
Hyperprolactinemia may cause bone loss but data on fractures are scanty. The aim of this study was to evaluate the prevalence of vertebral fractures in women with prolactin (PRL)-secreting adenoma. In this crosssectional study, 78 women (median age 45.5 years, range: 20-81) with PRL-secreting pituitary adenoma (66 with microadenoma and 12 with macroadenoma) and 156 control subjects, with normal PRL values and with comparable age to patients with hyperprolactinemia, were evaluated for vertebral fractures by a morphometric approach and for bone mineral density (BMD) by a dual-energy X-ray absorptiometry at lumbar spine. Vertebral fractures were shown in 25 patients with PRL-secreting adenoma (32.6%) and in 20 controls (12.8%, P \ 0.001). Fractured patients were significantly older (P \ 0.001) and had lower BMD T-score (P \ 0.001), longer duration of disease (P \ 0.001), higher serum PRL (P = 0.004) and lower serum IGF-I (P \ 0.001) values as compared to patients who did not fracture. The prevalence of vertebral fractures was significantly (P \ 0.001) higher in post-menopausal women with PRL-secreting adenoma as compared to premenopausal patients. Fractures occurred more frequently (P
Who reads High Prevalence of Radiological Vertebral Fractures in Women with Prolactin-secreting Pituitary Adenomas?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gherardo Mazziotti; Tatiana Mancini; Marilda Mormando; Ernesto De Menis; Antonio Bianchi; Mauro Doga; Teresa Porcelli; Pier Paolo Vescovi; Laura De Marinis; Andrea Giustina
- Publisher
- Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1386-341X)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)