Can I read Role of protein kinase C in transmembrane signaling on EtoBox?

Role of protein kinase C in transmembrane signaling by Yoshimi Takai; Kozo Kaibuchi; Terutaka Tsuda; Masahiko Hoshijima is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Role of protein kinase C in transmembrane signaling about?

Many extracellular signals elicit Ca2 + mobilization and diacylglycerol formation in their target cells. Diacylglycerol is derived from the receptor-linked phosphoinositide turnover and serves as a second messenger for the activation of protein kinase C in the presence of Ca2+ and phosphatidylserine. Unique diacylglycerols such as l-oleoyl-2-acetyl-glycerol, which activate intracellular protein kinase C when added to intact cells, have been synthesized. Tumor-promoting phorbol esters substitute for such diacylglycerols and directly activate protein kinase C in both intact cell and cell-free systems. Under appropriate conditions, the synthetic diacylglycerols and phorbol esters induce protein kinase C activation without Ca2+ mobilization, whereas Ca2+ ionophore A23 187 induces Ca2+ mobilization without protein kinase C activation. Using these substances, we have obtained evidence that both protein kinase C and Ca2+ are involved in and play a synergistic role in exocytosis, cell division, and other cellular functions. In this article, the role of protein kinase C in transmembrane signaling is discussed.

Who reads Role of protein kinase C in transmembrane signaling?

Author

Yoshimi Takai; Kozo Kaibuchi; Terutaka Tsuda; Masahiko Hoshijima

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0730-2312)

Published

1985

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)