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Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression by Dalhuisen, Iris; Ackermans, Eveline; Martens, Lieke; Mulders, Peter; Bartholomeus, Joey; de Bruijn, Alex; Spijker, Jan; van Eijndhoven, Philip; Tendolkar, Indira is a Medicine article available to read on EtoBox.
What is Longitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression about?
## Abstract Major depressive disorder (MDD) is amongst the most prevalent of psychiatric disorders. Unfortunately, a third of patients will not respond to conventional treatments and suffer from treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) has been proven effective in treating TRD. The research suggests that rTMS acts via neuroplastic effects on the brain, which can be measured by changes in hippocampal and amygdala volume as well as cortical thickness. This sham-controlled study investigates longitudinal effects of rTMS on the volumes of the hippocampus and amygdala and cortical thickness in patients with chronic TRD. 31 patients received 20 sessions of high-frequency rTMS (N = 15) or sham treatment (N = 16) over the left dorsolateral prefrontal cortex during 4 consecutive weeks. Using structural magnetic resonance imaging, we investigated longitudinal treatment effects on hippocampus and amygdala volume as well as thickness of the paralimbic cortex. We found no clinical differences between the active and sham rTMS group. Longitudinal changes in hippocampal and amygdala volume did not differ significantly, although males showed a signif
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- Author
- Dalhuisen, Iris; Ackermans, Eveline; Martens, Lieke; Mulders, Peter; Bartholomeus, Joey; de Bruijn, Alex; Spijker, Jan; van Eijndhoven, Philip; Tendolkar, Indira
- Publisher
- Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1433-8491)
- Published
- 2020
- Language
- EN
- ISBN
- 9780040602006
- Field
- Medicine (Health Sciences)