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Ionic and Pharmacologic Characteristics of Epithelial Cells in a Semi-intact Preparation of the Rat Ventral Prostate Gland by Maria E. Mycielska; Marek Szatkowski; Mustafa B.A. Djamgoz is a Medicine article available to read on EtoBox.

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## Background: The essential ionic and pharmacologic characteristics of epithelial cells within the ducts of the prostate gland are not well known. ## Methods: Experiments were carried out on segments of ventral prostate glands from adult male rats. by using sharp microelectrodes, intracellular epithelial cell and transepithelial (lumen) potentials were recorded in response to ionic substitution and application of ion channel blockers, hormones, and other pharmacologic agents related to prostatic function. ## Results: Membrane permeabilities to k(+), na(+), and cl(-) were found to account for approximately 43% of the resting membrane potential, whereas some 39% was likely to be metabolic in origin. the membrane potential also responded to adrenaline, acetylcholine, insulin, prolactin, testosterone, nerve growth factor, and nitric oxide. the lumen potential was found to be particularly sensitive to citrate, prolactin, and testosterone. ## Conclusion: It was concluded that the basal membrane potential of prostatic epithelial cells is associated with a relatively high na(+):k(+) permeability ratio and metabolic dependence. the hormonal and pharmacologic sensitivity observed is consist

Who reads Ionic and Pharmacologic Characteristics of Epithelial Cells in a Semi-intact Preparation of the Rat Ventral Prostate Gland?

Author

Maria E. Mycielska; Marek Szatkowski; Mustafa B.A. Djamgoz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)

Published

2002

Language

EN

Field

Medicine (Health Sciences)