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Synthesis, Characterization and Evaluation of Poly [Glucose Acrylate-methacrylic Acid] Hydrogels for Colon-specific Drug Delivery by Mehrdad Mahkam is a Materials Science article available to read on EtoBox.

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## Abstract New biodegradable polymeric hydrogels based on biocompatible materials, glucose acrylate (GA) and methacrylic acid (MAA) were designed and synthesized. In the first time, the glucose-6-acrylate-1,2,3,4-tetraacetate (GATA) monomer was prepared under mild conditions. The removal of protecting acetate groups from GATA will be carried out before the polymerization and then, the corresponding water soluble glycomonomer (GA) was obtained. This deprotected glycomonomer can be polymerized in aqueous media, which points to a way to obtain polymers with applications in biomedical and biochemical fields. Hydrogel synthesis was carried out by free-radical polymerization of the co-monomers using persulfate as an initiator and N,N′-methylenebisacrylamide as crosslinker. The hydrogels was characterized by FT-IR. Equilibrium swelling studies were carried out in enzyme-free simulated gastric and intestinal fluids (SGF and SIF, respectively). The swelling behaviour of the copolymers was dependent on the content of MAA groups and caused a decrease in gel swelling in pH 1 or an increase in gel swelling in pH 7.4. Model drug, 5-aminosalicylic acid (5-ASA) was entrapped into these hydrogels

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Author

Mehrdad Mahkam

Publisher

Walter de Gruyter GmbH

Published

2008

Language

EN

Field

Materials Science (Physical Sciences)