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The Stimulus–response Curve and Motor Unit Variability in Normal Subjects and Subjects with Amyotrophic Lateral Sclerosis by R. D. Henderson; G. R. Ridall; A. N. Pettitt; P. A. McCombe; J. R. Daube is a Medicine article available to read on EtoBox.

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## Abstract The behavior and stability of motor units (MUs) in response to electrical stimulation of different intensities can be assessed with the stimulus–response curve, which is a graphical representation of the size of the compound muscle action potential (CMAP) in relation to stimulus intensity. To examine MU characteristics across the whole stimulus range, the variability of CMAP responses to electrical stimulation, and the differences that occur between normal and disease states, the curve was studied in 11 normal subjects and 16 subjects with amyotrophic lateral sclerosis (ALS). In normal subjects, the curve showed a gradual increase in CMAP size with increasing stimulus intensity, although one or two discrete steps were sometimes observed in the upper half of the curve, indicating the activation of large MUs at higher intensities. In ALS subjects, large discrete steps, due to loss of MUs and collateral sprouting, were frequently present. Variability of the CMAP responses was greater than baseline variability, indicating variability of MU responses, and at certain levels this variability was up to 100 μVms. The stimulus–response curve shows differences between normal and A

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Author

R. D. Henderson; G. R. Ridall; A. N. Pettitt; P. A. McCombe; J. R. Daube

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)

Published

2006

Language

EN

Field

Medicine (Health Sciences)