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Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population by Kiyoshi Ichihara; Kensuke Saito; Yoshihisa Itoh is a Medicine article available to read on EtoBox.

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Background: To derive reference intervals (RIs) for cystatin C (CysC), we examined sources of variation in its serum concentration by multiple regression analysis. Methods: A total of 596 healthy subjects (30-75 years of age) who underwent an annual health check were chosen as candidate reference individuals who did not have any chronic illness requiring medication. Serum CysC was measured together with routine screening tests (basic clinical chemistry and complete blood count). Results: Multivariate analysis revealed that CysC concentrations were higher in males by an average of 0.082 mg/L. Levels were positively associated with age (q0.047 mg/L for every 10 years), body fat (BF%) and cigarette smoking, and negatively associated with alcohol consumption. A subgroup analysis revealed that the gender difference was not significant for those over 50 years of age. RIs were determined using a ''latent abnormal values exclusion method'' involving deletion of individuals with two or more abnormal results in the screening tests. RIs were partitioned into three categories by age and gender: 0.60-0.95 mg/L for males aged 30-50 years; 0.55-0.84 mg/L for females aged 30-50 years; and 0.64-1.0

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Author

Kiyoshi Ichihara; Kensuke Saito; Yoshihisa Itoh

Publisher

Walter de Gruyter GmbH & Co. KG; Walter de Gruyter GmbH (ISSN 1434-6621)

Published

2007

Language

EN

Field

Medicine (Health Sciences)