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Can I read Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma on EtoBox?
Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma by Ting Wang; Laura M. Fox; Desuo Wang is a Chemistry article available to read on EtoBox.
What is Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma about?
MS23 is a vasodilator with unique dual action pharmacological profile to inhibit type 4 PDE and antagonize L-type calcium channels. We validated an analytical protocol for MS23 in rat plasma using high performance liquid chromatography (HPLC). A C18 column and a phosphate/acetonitrite buffer were used for chromatographic separation. UV detection was performed at 307 nm. The calibration curve for MS23 was linear in the range from 50 to 10,000 ng/ml. The limit of quantification (LOQ) was 50 ng/ml. The results demonstrate that the method has linearity (R = 0.9989), specificity, and acceptable precision/accuracy. This method is simple, economic, and sufficient for in vivo pharmacokinetic studies on the compound.
Who reads Validation of HPLC analysis method of a novel antihypertensive agent MS23 in rat plasma?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Ting Wang; Laura M. Fox; Desuo Wang
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)
- Published
- 2006
- Language
- EN
- Field
- Chemistry (Physical Sciences)