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Inflammation Resolution and Specialized Pro-resolving Lipid Mediators in Chronic Rhinosinusitis by Peyton Z. Robinson; Daniel N. Frank; Vijay R. Ramakrishnan is a Medicine article available to read on EtoBox.

What is Inflammation Resolution and Specialized Pro-resolving Lipid Mediators in Chronic Rhinosinusitis about?

ABSTRACT Introduction In chronic rhinosinusitis (CRS), a complex pathophysiology results from varied pro-inflammatory stimuli but is consistently characterized by classic cellular, molecular, and microbial alterations. Normally, endogenous specialized pro-resolving mediators (SPM) actively promote resolution of inflammation through numerous pathways including those involved in host antimicrobial defense. However, these pathways appear to be disrupted in CRS. Areas covered This paper describes features of CRS in the context of chronic tissue inflammation, and potential mechanisms by which specialized pro-resolving mediators promote active resolution of tissue inflammation. Expert opinion Temporal phases of resolution must be tightly regulated to successfully resolve inflammation in CRS while preserving tissue functions such as barrier maintenance and special sensory function. Dysregulation of SPM enzymatic pathways has been recently shown in CRS and is associated with disease phenotypes and microbial colonization patterns. Current research in animal models and in vitro human cell culture, as well as human dietary studies, demonstrate relevant changes in cell signaling with lipid med

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Author

Peyton Z. Robinson; Daniel N. Frank; Vijay R. Ramakrishnan

Publisher

Informa UK Limited

Published

2023

Language

EN

Field

Medicine (Health Sciences)