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Can I read Maturation of Long-term Potentiation in the Hippocampal Dentate Gyrus of the Freely Moving Rat on EtoBox?
Maturation of Long-term Potentiation in the Hippocampal Dentate Gyrus of the Freely Moving Rat by Joseph D. Bronzino; Khamis Abu-Hasaballah; Dr. Robert J. Austin-LaFrance; Peter J. Morgane is a Neuroscience article available to read on EtoBox.
What is Maturation of Long-term Potentiation in the Hippocampal Dentate Gyrus of the Freely Moving Rat about?
The ability of the perforant path/dentate granule cell synapse of the hippocampal formation to establish and maintain enhanced levels of synaptic transmission in response to tetanization (longterm potentiation, LTP) was investigated in freely moving rats at 15, 30, and 90 days of age. Measures of 1) the slope of the population excitatory postsynaptic potential (EPSP), and 2) the population spike amplitude (PSA) obtained before, and at several times following tetanization, were used to evaluate the magnitude and duration of LTP as a function of age. Significant enhancement of both EPSP slope and PSA measures was obtained from animals of all three ages in response to perforant path tetanization. The initial degree of enhancement was essentially the same across the age groups, ranging from +27% to +38% of pretetanization levels for EPSP slope measures and +60% to +75% of pretetanization levels for PSA measures, obtained 15 min after tetanization. The duration of this enhancement obtained from animals of the preweaning group was significantly longer than that obtained from either 30-or 90-day-old animals. Enhanced measures of both EPSP slope and PSA decayed to baseline levels in these
Who reads Maturation of Long-term Potentiation in the Hippocampal Dentate Gyrus of the Freely Moving Rat?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Joseph D. Bronzino; Khamis Abu-Hasaballah; Dr. Robert J. Austin-LaFrance; Peter J. Morgane
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1050-9631)
- Published
- 1994
- Language
- EN
- Field
- Neuroscience (Life Sciences)