Can I read LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies on EtoBox?

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies by Martyna M. Grochowska; Ana Carreras Mascaro; Valerie Boumeester; Domenico Natale; Guido J. Breedveld; Hanneke Geut; Wiggert A. van Cappellen; Agnita J. W. Boon; Anneke J. A. Kievit; Esther Sammler; Piero Parchi; Pietro Cortelli; Dario R. Alessi; Wilma D. J. van de Berg; Vincenzo Bonifati; Wim Mandemakers; Netherlands Brain Bank is a Medicine article available to read on EtoBox.

What is LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies about?

Loss-of-function variants in the low-density lipoprotein receptor-related protein 10 (__LRP10__) gene have been associated with autosomal-dominant Parkinson’s disease (PD), PD dementia, and dementia with Lewy bodies (DLB). Moreover, __LRP10__ variants have been found in individuals diagnosed with progressive supranuclear palsy and amyotrophic lateral sclerosis. Despite this genetic evidence, little is known about the expression and function of LRP10 protein in the human brain under physiological or pathological conditions. To better understand how __LRP10__ variants lead to neurodegeneration, we first performed an in-depth characterisation of LRP10 expression in post-mortem brains and human-induced pluripotent stem cell (iPSC)-derived astrocytes and neurons from control subjects. In adult human brain, LRP10 is mainly expressed in astrocytes and neurovasculature but undetectable in neurons. Similarly, LRP10 is highly expressed in iPSC-derived astrocytes but cannot be observed in iPSC-derived neurons. In astrocytes, LRP10 is present at trans-Golgi network, plasma membrane, retromer, and early endosomes. Interestingly, LRP10 also partially co-localises and interacts with sortilin-rela

Who reads LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with Lewy bodies?

Author

Martyna M. Grochowska; Ana Carreras Mascaro; Valerie Boumeester; Domenico Natale; Guido J. Breedveld; Hanneke Geut; Wiggert A. van Cappellen; Agnita J. W. Boon; Anneke J. A. Kievit; Esther Sammler; Piero Parchi; Pietro Cortelli; Dario R. Alessi; Wilma D. J. van de Berg; Vincenzo Bonifati; Wim Mandemakers; Netherlands Brain Bank

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Life Sciences)