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What is Immune Tolerance to Gluten in Health about?

In healthy individuals, gluten is partially digested and tTG may modify gliadin without provoking an immune response due to immune tolerance. This tolerance prevents the activation of gluten-specific T cells and the production of autoantibodies, maintaining intestinal integrity. Celiac disease occurs when this tolerance is disrupted, particularly in genetically predisposed individuals with HLA-DQ2/DQ8.

Author

Angelo Madjarov

Language

EN