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The mechanisms of resistance to second- and third-generation ALK inhibitors and strategies to overcome such resistance by Naoki Haratake; Gouji Toyokawa; Takashi Seto; Tetsuzo Tagawa; Tasuro Okamoto; Koji Yamazaki; Sadanori Takeo; Masaki Mori is a Medicine article available to read on EtoBox.
What is The mechanisms of resistance to second- and third-generation ALK inhibitors and strategies to overcome such resistance about?
## Introduction: Anaplastic lymphoma kinase (alk) inhibitors are widely known to contribute to the long-term survival of -rearranged non-small cell lung cancer (nsclc) patients. based on clinical trial data, treatment with second- or third-generation alk inhibitors can be initiated after crizotinib therapy without analyzing resistance mechanisms, and some randomized trials have recently shown the superiority of second- or third-generation alk inhibitors over crizotinib as the initial treatment; however, the optimal treatment for patients who relapse while on second- or third-generation alk inhibitors is not well-defined. ## Areas covered: This review provides an overview of the mechanisms of resistance to second- or third-generation alk inhibitors that have been identified in both clinical and pre-clinical settings, and introduces strategies for overcoming resistance and discusses ongoing clinical trials. ## Expert opinion: The comprehensive elucidation of both -dependent and -independent resistance mechanisms is necessary to improve the prognosis of patients with -rearranged nsclc. liquid biopsy to clarify these mechanisms of resistance might play an important role in the near fut
Who reads The mechanisms of resistance to second- and third-generation ALK inhibitors and strategies to overcome such resistance?
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- Author
- Naoki Haratake; Gouji Toyokawa; Takashi Seto; Tetsuzo Tagawa; Tasuro Okamoto; Koji Yamazaki; Sadanori Takeo; Masaki Mori
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)