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Living with Female Rats Exposed to Restraint Stress During Pregnancy Caused Depressive‐like Behavior in Male Rats and Stress‐induced Apoptosis by Sayad Kocahan; Kubra Akillioglu; Leman Sencar; Leyla Sahin; Ozge Selin Cevik; Eylem Taskin; Celal Guven; Ayper Boga; Sait Polat is a Neuroscience article available to read on EtoBox.
What is Living with Female Rats Exposed to Restraint Stress During Pregnancy Caused Depressive‐like Behavior in Male Rats and Stress‐induced Apoptosis about?
## Abstract ## Objective Maternal mood disorders such as postpartum depression (PPD) can negatively affect the lives not only of mothers but also of partners. The purpose of this study investigates emotional behavior and hippocampal apoptosis alterations of the male live with a postpartum depressed female. ## Methods Pregnant rats in the stress group were exposed to restraint stress (RS). The male rats who shared the same cages were not exposed to RS. To explain the consequences of depressive‐like behavior and anxiety, animals were exposed to the forced swim test (FST), open‐field test (OFT), and elevated plus maze (EPM). The apoptotic cell number was detected by terminal deoxynucleotidyl transferase (Tdt)‐mediated dUTP biotin nick‐end labeling (TUNEL) staining. ## Results According to FST, PPD caused more immobility, reduced swimming, and climbing compared to control groups in the stressed female and male (p < 0.05). For the crossing number of squares in the center area, the main effect of the group was significant (p < 0.05). Stressed groups have a higher crossing number of squares in the center area compared to control groups. In the OFT, there was a significant increase in the
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- Author
- Sayad Kocahan; Kubra Akillioglu; Leman Sencar; Leyla Sahin; Ozge Selin Cevik; Eylem Taskin; Celal Guven; Ayper Boga; Sait Polat
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Neuroscience (Life Sciences)