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Can I read Potential pitfalls when interpreting plasma BNP levels in heart failure practice on EtoBox?
Potential pitfalls when interpreting plasma BNP levels in heart failure practice by Toshio Nishikimi; Yasuaki Nakagawa is a Medicine article available to read on EtoBox.
What is Potential pitfalls when interpreting plasma BNP levels in heart failure practice about?
B-type (or brain) natriuretic peptide (BNP) is synthesized in cardiac myocytes and released constitutively into the circulation. Pressure/volume overload, neurohumoral factors, cytokines, and ischemia enhance BNP gene expression, and then precursor proBNP is produced. It has been thought that proBNP is cleaved into active BNP molecule and inactive marker molecule NT-proBNP intracellularly by processing enzyme furin, and they are released into the circulation. However, recent studies have shown that considerable amount of uncleaved proBNP circulates in the blood. The commercially available BNP assay kits consist of two antibodies that sandwich the BNP molecule. Therefore, if proBNP is present, BNP assay kit cross-reacts to proBNP and measures it as BNP. Therefore, it should be noted that the current BNP value is proBNP plus BNP. BNP and NT-proBNP have been established as a biomarker for heart failure patients presenting dyspnea. But many pitfalls are present for interpreting the BNP value. For example, the presence of renal dysfunction, age, female sex, atrial fibrillation, inflammation, hyperthyroidism, use of sacubitril/valsartan, and macro-proBNPemia overestimate BNP value, where
Who reads Potential pitfalls when interpreting plasma BNP levels in heart failure practice?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Toshio Nishikimi; Yasuaki Nakagawa
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)