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Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABAA receptor β3 subunit genes and alcoholism in Mexican-Americans by Tamiko Konishi; Maria Calvillo; Ai-She Leng; Keh-Ming Lin; Yu-Jui Yvonne Wan is a Medicine article available to read on EtoBox.

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The etiology of alcohol dependence is a complex interaction of psychosocial and biologic factors. To study the impact of genetic factors that play an important role in an individual's vulnerability to alcohol abuse and dependence, we examined the genetic variations of the major neurotransmitter genes, including the dopamine D2 receptor (DRD2) TaqI A, B, and -141C insertion/deletion (Ins/Del) polymorphisms, the serotonin transporter-linked polymorphic region (5-HTTLPR), and the gamma-aminobutyric acid A (GABA A ) receptor β 3 subunit gene (GABRb3), for 130 Mexican-American alcoholic men and 251 nonalcoholic control subjects (105 men and 146 women). The genotype frequency for the DRD2 -141C Ins/Del allele was significantly different between alcoholic and control subjects (P ϭ .007). The frequency of the 5-HTTLPR short (S) allele was significantly higher in alcoholic individuals (61.5%) than in nonalcoholic control subjects (52.8%; P ϭ .021). When smokers were excluded from both control and alcoholic groups, the association between the DRD2 -141C Ins allele, as well as between the 5-HTTLPR S allele, and alcoholism became significant at both genotypic and allelic levels. No positive as

Who reads Polymorphisms of the dopamine D2 receptor, serotonin transporter, and GABAA receptor β3 subunit genes and alcoholism in Mexican-Americans?

Author

Tamiko Konishi; Maria Calvillo; Ai-She Leng; Keh-Ming Lin; Yu-Jui Yvonne Wan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)

Published

2004

Language

EN

Field

Medicine (Health Sciences)