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This document discusses pharmacoinformatics approaches to studying polyspecific proteins like ABC transporters. It summarizes the drug development process and highlights paradigm shifts like recognizing that many drugs have multiple targets. The document explores chemogenomics methods to map the chemical and biological spaces. It provides details on the ABC transporter P-glycoprotein, including its substrates, inhibitors, and physiological functions. The challenges of multispecificity for drug design are ou

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