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Effects of Retinoic Acid on Proliferation, Apoptosis, Cytotoxicity, Migration, and Invasion of Neuroblastoma Cells by A. Voigt; F. Zintl is a Medicine article available to read on EtoBox.

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## Abstract ## Background Because of the known property of less aggressiveness of differentiated cells compared to immatured cells all attempts are made to elucidate whether differentiation inducers possibly could be applied for neuroblastoma therapy. We are interested in examining the influence of retinoic acid (RA) on proliferation, apoptosis, cytotoxicity, migration, and invasion in dependence of the differentiation of neuroblastoma cells classified into N‐type (SK‐N‐FI, SH‐SY5Y), I‐type (SK‐PN‐DW), and S‐type (SK‐N‐LO, SK‐N‐MC) cells. ## Procedure Neuroblastoma cells were exposed to 10^−5^ M RA and 200 ng/ml camptothecin (CAM) (control substance for apoptosis). Proliferation, apoptosis, and cytotoxicity were quantified by photometric assays. The influence on migration and invasion of neuroblastoma cells was examined by a scratch‐test and by the measurement of the invasion through matrigel coated chamber inserts. ## Results In general, RA treatment induced proliferation inhibition predominantly in the cell lines SK‐PN‐DW (16%, __P__ < 0.05) and SK‐N‐MC (8%, (__P__ 0.05) and SH‐SY5Y (__P__ < 0.001) no proliferation inhibition was determined conforming with no detection of apopt

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Author

A. Voigt; F. Zintl

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)

Published

2003

Language

EN

Field

Medicine (Health Sciences)