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Prospective Study of Mustard Allergy: First Study with Double-blind Placebo-controlled Food Challenge Trials (24 Cases) by M. Morisset; D.-A. Moneret-Vautrin; F. Maadi; S. Frémont; L. Guénard; A. Croizier; G. Kanny is a Medicine article available to read on EtoBox.

What is Prospective Study of Mustard Allergy: First Study with Double-blind Placebo-controlled Food Challenge Trials (24 Cases) about?

**Background:** Mustard allergy accounts for 1.1% of food allergies in children. However, double‐blind placebo‐controlled food challenge trials (DB PCFCs) have not yet been proposed. **Objective:** To carry out DB PCFCs to determine the real frequency of mustard allergy in patients sensitized to mustard. **Methods:** A prospective study was conducted in 30 subjects aged 3–20 years presenting positive prick tests to ground mustard seeds (__Brassica nigra__), mustard flour (__B. juncea__), metabisulfite‐free strong mustard seasoning (__B. juncea__) and a commercialized allergenic extract (__B. nigra__). Twenty‐seven subjects were screened for mustard‐specific immunoglobulin E (IgE). PCFCs were carried out either DB or single blind (SB) with up to 1340 mg of metabisulfite‐free seasoning. **Results:** The mean diameter of the wheal induced by prick tests with the allergenic extract was lower (n.s.) than that induced by the native mustard products: 5.8 mm (1.5–15) __vs__ 6.9 mm (0.5–18) for __B. nigra__ ground seeds, 7.8 mm (1–20) for __B. juncea__ flour and 9.7 mm (3–20) for the strong mustard seasoning. The diameter of the wheal induced by the allergenic extract was significantly diff

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Author

M. Morisset; D.-A. Moneret-Vautrin; F. Maadi; S. Frémont; L. Guénard; A. Croizier; G. Kanny

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-4538)

Published

2003

Language

EN

Field

Medicine (Health Sciences)