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Can I read A Transgenic Mouse Model of the Slow-channel Syndrome on EtoBox?
A Transgenic Mouse Model of the Slow-channel Syndrome by Christopher M. Gomez; Bula B. Bhattacharyya; Pierre Charnet; John W. Day; Cesar Labarca; Robert L. Wollmann; Edward H. Lambert is a Medicine article available to read on EtoBox.
What is A Transgenic Mouse Model of the Slow-channel Syndrome about?
To investigate the effect of acetylcholine receptor (AChR) mutations on neuromuscular transmission and to develop a model for the human neuromuscular disease, the slow-channel syndrome, we generated transgenic mice with abnormal AChRs using a 6 subunit with a mutation in the ion channel domain. In three transgenic lines, nerve-evoked end-plate currents and spontaneous miniature end-plate currents (MEPCs) had prolonged decay phases and MEPC amplitudes were reduced by 33%. Single nerve stimuli elicited repetitive compound muscle action potentials in vivo. Transgenic mice were abnormally sensitive to the neuromuscular blocker, curare. These observations demonstrate that we can predictably alter AChR function, synaptic responses, and muscle fiber excitation in vivo by overexpressing subunits containing well-defined mutations. Furthermore these data support the hypothesis that the electrophysiological findings in the neuromuscular disorder, the slow-channel syndrome, are due to mutant AChRs.
Who reads A Transgenic Mouse Model of the Slow-channel Syndrome?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Christopher M. Gomez; Bula B. Bhattacharyya; Pierre Charnet; John W. Day; Cesar Labarca; Robert L. Wollmann; Edward H. Lambert
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0148-639X)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)