About this Biochemistry, Genetics and Molecular Biology article

Vibrational circular dichroism of poly(γ-benzyl-L-glutamate) by R. D. Singh; T. A. Keiderling is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

Vibrational circular dichroism (VCD), the differential absorption of circularly polarized light by vibrational transitions, is a new technique of potential use for stereochemical analysis.13 Recent instrumental developments have allowed extension of the VCD technique down to 1250 cm-l, thereby encompassing some of the characteristic amide Vibrations of polypeptides? The polarized ir absorption spectra of these bands have in the past been extensively utilized to analyze the secondary structure of such polymers.5 Use of VCD should add another dimension to their conformational utility. Schellman6 and Snir et al.7 have previously reported predictions of the VCD that might result from the coupling of the monomer vibrations in a-helical, parallel P-sheet, and antiparallel 0-sheet polypeptide structures. Using the coupling parameters of Miyazawa and Blout,B large sigmoidally shaped VCD of opposite sense was predicted for both the amide I (-1658 cm-l) and amide I1 (-15550 cm-') bands of the c~-helix.~ However, using the parameters of Krimm: the amide I1 band was predicted to have a substantially reduced magnitude and a sigmoidal shape of the same sense as predicted for the amide I band. Bo

Author

R. D. Singh; T. A. Keiderling

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0006-3525)

Published

1981

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)