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Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system by Cristiane Helena Squarize; Rogério Moraes Castilho; Décio Santos Pinto Jr is a Medicine article available to read on EtoBox.

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## Abstract __PTEN__ is a tumor suppressor gene that encodes a dual phosphatase protein capable of modulating membrane receptors and interaction of the cell and extracellular stimuli. __PTEN__ regulates cell physiology such as division, differentiation/apoptosis and also migration and adhesion. The expression of __PTEN__ was evaluated by immunohistochemistry in OSCC and compared to a well‐established histological malignancy grading system. The well‐differentiated OSCC were 59.1% and poorly differentiated were 40.9%. According to __PTEN__ expression, the cases were 45.5% positive (the entire tumor showed stained), 22.7% mixed (both negative and positive cells were present) and 31.8% negative (no staining was seen in the tumor cells). __PTEN__ expression in OSCC was related to the malignancy grade (__P__ < 0.0005). Aggressive tumors with a high score of malignancy did not express __PTEN__, and clearly, the __PTEN__ expression was present in the epithelium adjacent to the tumor. Negative cells were in the invasion border of the tumor. This result suggests that __PTEN__ is related to histologic pattern and biological behavior of OSCC and may be a used as a prognostic marker in the futu

Who reads Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the histological malignancy grading system?

Author

Cristiane Helena Squarize; Rogério Moraes Castilho; Décio Santos Pinto Jr

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0904-2512)

Published

2002

Language

EN

Field

Medicine (Health Sciences)