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Can I read The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy on EtoBox?
The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy by Chen, Danqing ;Tan, Shuguang ;Zhang, Hao ;Wang, Haiyuan ;He, Weiwu ;Shi, Rui ;Tong, Zhou ;Zhu, Jianhua ;Cheng, Hao ;Gao, Shan ;Chai, Yan ;Qi, Jianxun ;Xiao, Minghui ;Yan, Jinghua ;Gao, George F. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy about?
## Summary Programmed cell death 1 (PD-1)/PD-1 ligand-1 (PD-L1)-blocking monoclonal antibodies (mAbs) have taken center stage for tumor immune checkpoint therapy. Identification of the “hotspots” on PD-1 for mAbs will help to develop next-generation oral deliverable agents with long-lasting efficacy. Here, we identified two PD-1-targeting mAbs, GY-5 and GY-14, with PD-1/PD-L1-blocking efficacy. Complex structural information revealed that both mAbs mainly bind to the FG loop of PD-1, which also contributes multiple interactions with PD-L1. The FG loop adopts substantially varied conformations upon binding to different mAbs, providing a novel targetable region for the development of PD-1-specific biologics and small chemical molecules. Glycosylation modifications of PD-1 could be observed in three of the four potential N-linked glycosylation sites. However, the binding of GY-5 and GY-14 to PD-1 was not affected by glycosylation. These findings broaden our understanding of the mechanism of anti-PD-1 mAbs and provide insight into the development of agents targeting PD-1.
Who reads The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Chen, Danqing ;Tan, Shuguang ;Zhang, Hao ;Wang, Haiyuan ;He, Weiwu ;Shi, Rui ;Tong, Zhou ;Zhu, Jianhua ;Cheng, Hao ;Gao, Shan ;Chai, Yan ;Qi, Jianxun ;Xiao, Minghui ;Yan, Jinghua ;Gao, George F.
- Publisher
- Elsevier ; Elsevier Inc.; [Cambridge MA]: Cell Press Elsevier Inc.; Elsevier BV (ISSN 2589-0042)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)