Opening book details…
Can I read Comparison of Animal Models for the Study of Nonalcoholic Fatty Liver Disease on EtoBox?
Comparison of Animal Models for the Study of Nonalcoholic Fatty Liver Disease by Qing Zheng; Min Zhu; Xin Zeng; Wen Liu; Fudong Fu; Xiaoyu Li; Guangneng Liao; Yanrong Lu; Younan Chen is a Medicine article available to read on EtoBox.
What is Comparison of Animal Models for the Study of Nonalcoholic Fatty Liver Disease about?
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases, and there is still no effective treatment for its advanced stage, nonalcoholic steatohepatitis (NASH). An ideal animal model of NAFLD/NASH is urgently needed for preclinical studies. However, the models reported previously are quite heterogeneous due to differences in animal strains, feed formulations, evaluation indicators, etc. Here, we report five NAFLD mouse models we developed in previous studies and comprehensively compared their characteristics. The high-fat diet (HFD) model is time-consuming and is characterized by early insulin resistance and slight liver steatosis at 12 weeks. Still, inflammation and fibrosis are rare, even at 22 weeks. The high fat, high fructose, and high cholesterol diet (FFC) exacerbates glucose and lipid metabolism disorders, showing distinct hypercholesterolemia, steatosis, and mild inflammation at 12 w. An FFC diet combined with streptozotocin (STZ) is a novel model that speeds up the process of lobular inflammation and fibrosis. The STAM model also used a combination of FFC and STZ but employs newborn mice and shows the fastest formation of fibrosis nodul
Who reads Comparison of Animal Models for the Study of Nonalcoholic Fatty Liver Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Qing Zheng; Min Zhu; Xin Zeng; Wen Liu; Fudong Fu; Xiaoyu Li; Guangneng Liao; Yanrong Lu; Younan Chen
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)