Can I read circStrn3 is involved in bone cancer pain regulation in a rat model on EtoBox?

circStrn3 is involved in bone cancer pain regulation in a rat model by Yiwen Zhang; Xiaoxia Zhang; Zumin Xing; Shuyi Tang; Hanwen Chen; Zhongqi Zhang; Jiyuan Li; Yalan Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is circStrn3 is involved in bone cancer pain regulation in a rat model about?

## Abstract Bone cancer pain (BCP) is a common chronic pain that is caused by a primary or metastatic bone tumor. More detailed molecular mechanisms of BCP are warranted. In this study, we established a BCP rat model. The von Frey hair test, body weight, and hematoxylin and eosin staining were employed. We screened differentially expressed circRNAs (DECs) between the BCP group and sham group. The results revealed that 850 DECs were significantly up-regulated and 644 DECs were significantly down-regulated in the BCP group. Furthermore, we identified 1177 differentially expressed genes (DEGs) significantly up-regulated and 565 DEGs significantly down-regulated in the BCP group. Gene Ontology annotation of all 1742 DEGs revealed that biological regulation of metabolic processes, cellular processes, and binding were the top enriched terms. For Kyoto Encyclopedia of Genes and Genomes analysis, phagosome, HTLV-I infection, proteoglycans in cancer, and herpes simplex infection were significantly enriched in this study. In addition, we identified four selected circRNAs, chr6:72418120|72430205, chr20:7561057|7573740, chr18:69943105|69944476, and chr5:167516581|167558250, by quantitative rea

Who reads circStrn3 is involved in bone cancer pain regulation in a rat model?

Author

Yiwen Zhang; Xiaoxia Zhang; Zumin Xing; Shuyi Tang; Hanwen Chen; Zhongqi Zhang; Jiyuan Li; Yalan Li

Publisher

China Science Publishing & Media Ltd.

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)