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Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia by Stefano Molica; Giovanna Cutrona; Gaetano Vitelli; Rosanna Mirabelli; Matteo Molica; Giovanna Digiesi; Domenico Ribatti; Manlio Ferrarini; Angelo Vacca is a Medicine article available to read on EtoBox.

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We wondered whether there was any association between the extent of increased angiogenesis and IgV H gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expression (P = 0.03), CD38-expression (P = 0.03) and mutational status of IgV H (P = 0.005). The same did not apply when correlations were sought with either bone marrow angiogenesis or serum levels of basic fibroblatic growth factor (FGF-2). Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgV H status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.

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Author

Stefano Molica; Giovanna Cutrona; Gaetano Vitelli; Rosanna Mirabelli; Matteo Molica; Giovanna Digiesi; Domenico Ribatti; Manlio Ferrarini; Angelo Vacca

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)

Published

2007

Language

EN

Field

Medicine (Health Sciences)