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Prevalence Study of PD-L1 SP142 Assay in Metastatic Triple-negative Breast Cancer by Yijin Li; Bharathi Vennapusa; Ching-Wei Chang; David Tran; Rin Nakamura; Teiko Sumiyoshi; Priti Hegde; Luciana Molinero is a Medicine article available to read on EtoBox.

What is Prevalence Study of PD-L1 SP142 Assay in Metastatic Triple-negative Breast Cancer about?

Metastatic triple-negative breast cancer (mTNBC) is the most aggressive breast cancer subtype. Programmed death ligand 1 (PD-L1) on immune cells (IC) using the VENTANA SP142 assay is linked to improved clinical outcome in atezolizumab plus nab—paclitaxel-treated patients with mTNBC in the IMpassion130 study. The goal of the current study was to evaluate prevalence of VENTANA SP142 PD-L1 assay by anatomic location in 670 histologically confirmed TNBC cases from subjects with metastatic disease screened for the phase 1 study PCD4989g (NCT01375842). PD-L1 immunohistochemistry was centrally tested on tumor cells (TC) and on tumor infiltrating IC, following manufacturer’s instructions. At a 1% cutoff, tumor PD-L1 was more prevalent in IC than TC: 46% were PD-L1 IC+/TC−, 3% were PD-L1 IC−/TC+, and 10% were PD-L1 IC+/TC+. PD-L1 IC and TC immunostaining correlated with __CD274__ RNA expression, as assessed by fluidigm. Analyses of anatomic locations suggest that prevalence of PD-L1 IC+ was highest in lymph nodes (65.0%), lowest in liver metastases (26.9%), while breast tissue was intermediate (57.1%). Matched paired samples from the same subject collected synchronously or asynchronously sh

Who reads Prevalence Study of PD-L1 SP142 Assay in Metastatic Triple-negative Breast Cancer?

Author

Yijin Li; Bharathi Vennapusa; Ching-Wei Chang; David Tran; Rin Nakamura; Teiko Sumiyoshi; Priti Hegde; Luciana Molinero

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2020

Language

EN

Field

Medicine (Health Sciences)