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Cyclic Cell‐Penetrating Peptides with Single Hydrophobic Groups by Jian Song; Ziqing Qian; Ashweta Sahni; Kuangyu Chen; Dehua Pei is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cyclic Cell‐Penetrating Peptides with Single Hydrophobic Groups about?

A new family of cyclic cell-penetrating peptides (CPPs) has been discovered; they differ from previously reported cyclic CPPs by containing only a single hydrophobic residue. The optimal CPP structure consists of four arginine residues and a hydrophobic residue with a long alkyl chain (e.g., a decyl group) in a cyclohexapeptide ring. The most active member of this family, CPP 17, has an intrinsic cellular entry efficiency similar to that of cyclic CPP12, the most active CPP reported to date. However, CPP 17 is 2.8 times more active than CPP12 under high serum protein concentrations, presumably because of the lower protein binding. CPP 17 enters the cell primarily by direct translocation at a relatively low concentration (≥5 μm).

Who reads Cyclic Cell‐Penetrating Peptides with Single Hydrophobic Groups?

Author

Jian Song; Ziqing Qian; Ashweta Sahni; Kuangyu Chen; Dehua Pei

Publisher

Wiley

Published

2019

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)