Can I read Different Roles for Inhibition in the Rhythm-generating Respiratory Network on EtoBox?

Different Roles for Inhibition in the Rhythm-generating Respiratory Network by Harris, Kameron Decker; Dashevskiy, Tatiana; Mendoza, Joshua; Garcia, Alfredo J.; Ramirez, Jan-Marino; Shea-Brown, Eric is a scholarly article available to read on EtoBox.

What is Different Roles for Inhibition in the Rhythm-generating Respiratory Network about?

Unraveling the interplay of excitation and inhibition within rhythm-generating networks remains a fundamental issue in neuroscience. We use a biophysical model to investigate the different roles of local and long-range inhibition in the respiratory network, a key component of which is the pre-B\"otzinger complex inspiratory microcircuit. Increasing inhibition within the microcircuit results in a limited number of out-of-phase neurons before rhythmicity and synchrony degenerate. Thus, unstructured local inhibition is destabilizing and cannot support the generation of more than one rhythm. A two-phase rhythm requires restructuring the network into two microcircuits coupled by long-range inhibition in the manner of a half-center. In this context, inhibition leads to greater stability of the two out-of-phase rhythms. We support our computational results with in vitro recordings from mouse pre-B\"otzinger complex. Partial excitation block leads to increased rhythmic variability, but this recovers following blockade of inhibition. Our results support the idea that local inhibition in the pre-B\"otzinger complex is present to allow for descending control of synchrony or robustness to adve

Author

Harris, Kameron Decker; Dashevskiy, Tatiana; Mendoza, Joshua; Garcia, Alfredo J.; Ramirez, Jan-Marino; Shea-Brown, Eric

Published

2016

Language

EN