Can I read Non-Trapping PARP1 Degraders Explained on EtoBox?

Non-Trapping PARP1 Degraders Explained by Rachel Heap is a document available to read on EtoBox.

What is Non-Trapping PARP1 Degraders Explained about?

1) PARP1 is a nuclear protein involved in DNA damage response and its enzymatic function is to catalyze protein poly-ADP-ribosylation. 2) PARP inhibitors (PARPi) are thought to kill tumor cells via two mechanisms: PARP1 catalytic inhibition and PARP1 trapping. However, the relative contribution of these two pathways is unclear. 3) The authors designed small molecule PARP degraders based on the proteolysis targeting chimera (PROTAC) approach to selectively degrade PARP1. This strategy could pharmacologic

Author

Rachel Heap

Language

EN