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Effect of Topically Applied Sulphur Mustard on Antioxidant Enzymes in Blood Cells and Body Tissues of Rats by K. Husain; S. N. Dube; K. Sugendran; R. Singh; S. Das Gupta; S. M. Somani is a Environmental Science article available to read on EtoBox.

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The effect of sulphur mustard (0.5 LD~,,, percutaneous) on antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px)) in blood cells (erythrocytes (RBC), leucocytes (WBC) and platelets) and body tissues (liver, kidney, spleen and brain) of rats has been investigated 24 h post exposure. The SOD activity was significantly decreased in WBC, platelets, spleen and brain as compared to control. The CAT activity was significantly inhibited in RBC, WBC and spleen as compared to control. The GSH-Px activity was significantly depressed in WBC, spleen and liver as compared to control. It is concluded that sulphur mustard at a sublethal dose inhibited antioxidant enzyme activities in WBC and spleen. Thus, antioxidant enzymes in lymphatic tissues may be used as suitable models for assessing mustard oxygen species in sulphur mustard intoxication. toxicity. The study suggests the formation of reactive

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Author

K. Husain; S. N. Dube; K. Sugendran; R. Singh; S. Das Gupta; S. M. Somani

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0260-437X)

Published

1996

Language

EN

Field

Environmental Science (Physical Sciences)