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Prostate cancer and prostate bed SPECT imaging with ProstaScint®: Semiquantitative correlation with prostatic biopsy results by Sodee, D. Bruce; Ellis, Rodney J.; Samuels, Michael A.; Spirnak, J. Patrick; Poole, Wayne F.; Riester, Clifford; Martanovic, Dawn M.; Stonecipher, Robert; Bellon, Errol M. is a Medicine article available to read on EtoBox.

What is Prostate cancer and prostate bed SPECT imaging with ProstaScint®: Semiquantitative correlation with prostatic biopsy results about?

BACKGROUND. ProstaScint (Cytogen Corporation, Princeton, NJ) murine monoclonal antibody imaging is FDA-approved for imaging of prostate cancer patients at high risk for metastatic disease and patients postprostatectomy with a rising serum prostate-specific antigen (PSA) level. ProstaScint is a murine monoclonal antibody which targets prostate-specific membrane antigen (PSMA). PSMA expression is upregulated in primary and metastatic prostate cancer. FDA Cytogen (Princeton, NJ) protocol studies using 111 indium-labeled ProstaScint revealed correlation between areas of increased concentration in the prostate and biopsy-proven tumors in patients imaged pretherapy. METHODS. In our study, four transverse, single-photon emission tomography (SPECT) images were isolated and regions of interest were selected and correlated with pretherapy prostate biopsy results. Prostate cancer and normal tissue prostate/muscle background (P/M) ratios were derived, so that postprostatectomy/radiation therapy patients could be evaluated for the presence of residual prostate cancer. Twenty-three pretherapy prostate cancer patients with quadrant/sextant biopsies had SPECT 96-hr 111 indium ProstaScint pelvic im

Who reads Prostate cancer and prostate bed SPECT imaging with ProstaScint®: Semiquantitative correlation with prostatic biopsy results?

It is typically read by researchers, students, and practitioners in Medicine.

Author
Sodee, D. Bruce; Ellis, Rodney J.; Samuels, Michael A.; Spirnak, J. Patrick; Poole, Wayne F.; Riester, Clifford; Martanovic, Dawn M.; Stonecipher, Robert; Bellon, Errol M.
Publisher
John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0270-4137)
Published
1998
Language
EN
Field
Medicine (Health Sciences)

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