Opening book details…
Can I read Contactin-1 autoimmunity on EtoBox?
Contactin-1 autoimmunity by Divyanshu Dubey; Josephe A. Honorat; Shahar Shelly; Christopher J. Klein; Lars Komorowski; John R. Mills; Stefanie Brakopp; Christian Probst; Vanda A. Lennon; Sean J. Pittock; Andrew McKeon is a Medicine article available to read on EtoBox.
What is Contactin-1 autoimmunity about?
## Objective To determine serologic characteristics, frequency, phenotype, paraneoplastic associations, and electrodiagnostic and histopathologic features accompanying contactin-1 autoimmunity. ## Methods Archived sera known to produce synaptic tissue-based immunofluorescence patterns were reevaluated, and contactin-1 specificity was confirmed by recombinant protein assays. Screening of 233 chronic/relapsing demyelinating neuropathies for additional cases was performed. ## Results We identified 10 contactin-1 IgG seropositive cases. Frequency of contactin-1 immunoglobulin (Ig) G among tested Mayo Clinic chronic/relapsing demyelinating neuropathies was 2%. Sensory predominant presentations (n = 9, 90%), neuropathic pain (n = 6, 60%), and subacute progression (n = 5, 50%) were commonly encountered among contactin-1 neuropathies. Two patients had chronic immune sensory polyradiculopathy-like phenotype at presentation. Electrodiagnostic studies were consistent with demyelination (slowed conduction velocities and/or prolonged distal latencies) without conduction block. Markedly elevated CSF protein (median 222 mg/dL, range 69–960 mg/dL), thickening/gadolinium enhancement of nerve roots
Who reads Contactin-1 autoimmunity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Divyanshu Dubey; Josephe A. Honorat; Shahar Shelly; Christopher J. Klein; Lars Komorowski; John R. Mills; Stefanie Brakopp; Christian Probst; Vanda A. Lennon; Sean J. Pittock; Andrew McKeon
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)