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This document presents the first validated bioanalytical LC–MS/MS assay for quantifying ponatinib and its active metabolite N-desmethyl ponatinib in mouse plasma. The assay demonstrated high accuracy and precision across specified concentration ranges and was successfully applied in a pharmacokinetic study after oral administration of ponatinib to mice. The method offers a sensitive and selective approach suitable for studies involving low sample volumes, adhering to international guidelines for bioanalytic

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rao.tirri22

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EN