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Projection to latent pathways (PLP): a constrained projection to latent variables (PLS) method for elementary flux modes discrimination by Ana R Ferreira; João ML Dias; Ana P Teixeira; Nuno Carinhas; Rui MC Portela; Inês A Isidro; Moritz von Stosch; Rui Oliveira is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Projection to latent pathways (PLP): a constrained projection to latent variables (PLS) method for elementary flux modes discrimination about?
## Background Elementary flux modes (EFM) are unique and non-decomposable sets of metabolic reactions able to operate coherently in steady-state. A metabolic network has in general a very high number of EFM reflecting the typical functional redundancy of biological systems. However, most of these EFM are either thermodynamically unfeasible or inactive at pre-set environmental conditions. ## Results Here we present a new algorithm that discriminates the "active" set of EFM on the basis of dynamic envirome data. The algorithm merges together two well-known methods: projection to latent structures (PLS) and EFM analysis, and is therefore termed projection to latent pathways (PLP). PLP has two concomitant goals: (1) maximisation of correlation between EFM weighting factors and measured envirome data and (2) minimisation of redundancy by eliminating EFM with low correlation with the envirome. ## Conclusions Overall, our results demonstrate that PLP slightly outperforms PLS in terms of predictive power. But more importantly, PLP is able to discriminate the subset of EFM with highest correlation with the envirome, thus providing in-depth knowledge of how the environment controls core cell
Who reads Projection to latent pathways (PLP): a constrained projection to latent variables (PLS) method for elementary flux modes discrimination?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ana R Ferreira; João ML Dias; Ana P Teixeira; Nuno Carinhas; Rui MC Portela; Inês A Isidro; Moritz von Stosch; Rui Oliveira
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2006]-; Springer Science and Business Media LLC (ISSN 1752-0509)
- Published
- 2011
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)