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Sarcocystis neurona infections in raccoons (Procyon lotor): evidence for natural infection with sarcocysts, transmission of infection to opossums (Didelphis virginiana), and experimental induction of neurologic disease in raccoons by J.P Dubey; W.J.A Saville; J.F Stanek; D.S Lindsay; B.M Rosenthal; M.J Oglesbee; A.C Rosypal; C.J Njoku; R.W Stich; O.C.H Kwok; S.K Shen; A.N Hamir; S.M Reed is a Immunology and Microbiology article available to read on EtoBox.

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Equine protozoal myeloencephalitis (EPM) is a serious neurologic disease of horses in the Americas and Sarcocystis neurona is the most common etiologic agent. The distribution of S. neurona infections follows the geographical distributions of its definitive hosts, opossums (Didelphis virginiana, Didelphis albiventris). Recently, cats and skunks were reported as experimental and armadillos as natural intermediate hosts of S. neurona. In the present report, raccoons (Procyon lotor) were identified as a natural intermediate host of S. neurona. Two laboratory-raised opossums were found to shed S. neurona-like sporocysts after ingesting tongues of naturally-infected raccoons. Interferon-gamma gene knockout (KO) mice fed raccoon-opossum-derived sporocysts developed neurologic signs. S. neurona was identified immunohistochemically in tissues of KO mice fed sporocysts and the parasite was isolated in cell cultures inoculated with infected KO mouse tissues. The DNA obtained from the tongue of a naturally-infected raccoon, brains of KO mice that had neurological signs, and from the organisms recovered in cell cultures inoculated with brains of neurologic KO mice, corresponded to that of S. n

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Author

J.P Dubey; W.J.A Saville; J.F Stanek; D.S Lindsay; B.M Rosenthal; M.J Oglesbee; A.C Rosypal; C.J Njoku; R.W Stich; O.C.H Kwok; S.K Shen; A.N Hamir; S.M Reed

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2001

Language

EN

Field

Immunology and Microbiology (Life Sciences)