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Can I read Probing the Permeation Enhancement of Mefenamic Acid by Ethanol Across Full-thickness Skin, Heat-separated Epidermal Membrane and Heat-separated Dermal Membrane on EtoBox?
Probing the Permeation Enhancement of Mefenamic Acid by Ethanol Across Full-thickness Skin, Heat-separated Epidermal Membrane and Heat-separated Dermal Membrane by Charles M. Heard; Cerian Screen is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Probing the Permeation Enhancement of Mefenamic Acid by Ethanol Across Full-thickness Skin, Heat-separated Epidermal Membrane and Heat-separated Dermal Membrane about?
The permeation enhancement of mefenamic acid by ethanol across full-thickness porcine skin, heat-separated epidermal membrane and heatseparated dermal membrane has been probed. Two donor phases saturated with mefenamic acid were used: (1) PEG400; (2) PEG400 with 10% ethanol: these were applied to membranes mounted in Franz diffusion-type cells with 30 mg ml -1 cetrimide as receptor phase (n ≥ 5). Across full-thickness skin, the flux was below the limit of detection from PEG400, but with the inclusion of 10% ethanol was 0.83 g cm -2 h -1 . Across heat-separated epidermal membrane the flux from PEG was 11.9 ± 2.4 g cm -2 h -1 with a 2.42× increase in flux observed when 10% ethanol was present (p = 0.0095). Across heat-separated dermal membrane the flux from PEG400 was 0.62 ± 0.13 g cm -2 h -1 , with a 2.34× increase in flux observed when 10% ethanol was present (p = 0.0027). To conclude, complexation and co-permeation with ethanol via a pull effect was confirmed as the mechanism of enhanced skin permeation of mefenamic acid. Full thickness skin provides a more effective barrier than either isolated dermis or epidermis, casting doubt over the use of heat-separated epidermal membranes
Who reads Probing the Permeation Enhancement of Mefenamic Acid by Ethanol Across Full-thickness Skin, Heat-separated Epidermal Membrane and Heat-separated Dermal Membrane?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Charles M. Heard; Cerian Screen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2008
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)