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What is Temperature Impact on IgG Acidic Variants about?

This study investigated the effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies produced in Chinese hamster ovary (CHO) cell culture. The researchers found that an improvement in monoclonal antibody titer was accompanied by an increase in acidic charge variants. Using a Plackette-Burman design, they identified temperature shift as the most influential factor affecting acidic charge variant levels. Further experiments showed that shifting to a lower temperature and do

Author

IRFAN AHANGER

Language

EN