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Are COPD Prescription Patterns Aligned with Guidelines? Evidence from a Canadian Population-Based Study by Taraneh Bahremand; Mahyar Etminan; Nardin Roshan-Moniri; Mary A De Vera; Hamid Tavakoli; Mohsen Sadatsafavi is a Medicine article available to read on EtoBox.

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## Background In contemporary guidelines for the management of Chronic Obstructive Pulmonary Disease (COPD), the history of acute exacerbations plays an important role in the choice of long-term inhaled therapies. This study aimed at evaluating population-level trends of filled inhaled prescriptions over the time course of COPD and their relation to the history of exacerbations. ## Methods We used administrative health databases in British Columbia, Canada (1997–2015), to create a retrospective incident cohort of individuals with diagnosed COPD. We quantified long-acting inhaled medication prescriptions within each year of follow-up and documented their trend over the time course of COPD. Using generalized linear models, we investigated the association between the frequent exacerbator status (≥2 moderate or ≥1 severe exacerbation(s) in the previous 12 months) and filling a prescription after a physician visit. ## Results 132,004 COPD patients were included (mean age 68.6, 49.2% female). The most common medication class during the first year of diagnosis was inhaled corticosteroids (ICS, used by 49.9%), followed by long-acting beta-2 adrenoreceptor agonists (LABA, 31.8%). Long-actin

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Author

Taraneh Bahremand; Mahyar Etminan; Nardin Roshan-Moniri; Mary A De Vera; Hamid Tavakoli; Mohsen Sadatsafavi

Publisher

Dove

Published

2021

Language

EN

Field

Medicine (Health Sciences)