Can I read Cyclodextrin-assisted SERS determination of fluoroquinolone antibiotics in urine and blood plasma on EtoBox?

Cyclodextrin-assisted SERS determination of fluoroquinolone antibiotics in urine and blood plasma by Natalia E. Markina; Alexey V. Markin; Dana Cialla-May is a Chemistry article available to read on EtoBox.

What is Cyclodextrin-assisted SERS determination of fluoroquinolone antibiotics in urine and blood plasma about?

This paper describes the use of cyclodextrins (CDs) to improve the determination of fluoroquinolone antibiotics in human body fluids using surface-enhanced Raman spectroscopy (SERS). CDs were used to (i) prepare the CD-SERS substrate (synthesis and stabilization of silver nanoparticles), (ii) increase the sensitivity of the assay by enhancing the interaction between analyte molecules and the substrate, and (iii) improve the analysis accuracy by reducing the interaction between the substrate and endogenous components of body fluids. Two native CDs (α-CD and β-CD) and two of their derivatives with hydroxypropyl groups were tested, and the best results were obtained with CD-SERS substrate prepared using native β-CD. The CD-SERS assay has been developed and optimized for the determination of commonly used and structurally related fluoroquinolones (ciprofloxacin, norfloxacin, pefloxacin, and levofloxacin) in urine and blood plasma samples. Importantly, the non-significant difference in the interaction of the CD-modified SERS substrate with various fluoroquinolones has been successfully used to develop a versatile assay suitable for the analyte-class-specific analysis. Calibration plots

Who reads Cyclodextrin-assisted SERS determination of fluoroquinolone antibiotics in urine and blood plasma?

Author

Natalia E. Markina; Alexey V. Markin; Dana Cialla-May

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Chemistry (Physical Sciences)