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Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management by Ameldina Ceric; Teresa L. May; Anna Lybeck; Tobias Cronberg; David B. Seder; Richard R. Riker; Christian Hassager; Jesper Kjaergaard; Zana Haxhija; Hans Friberg; Josef Dankiewicz; Niklas Nielsen is a Medicine article available to read on EtoBox.

What is Cardiac Arrest Treatment Center Differences in Sedation and Analgesia Dosing During Targeted Temperature Management about?

## Abstract ## Background Sedation and analgesia are recommended during targeted temperature management (TTM) after cardiac arrest, but there are few data to provide guidance on dosing to bedside clinicians. We evaluated differences in patient-level sedation and analgesia dosing in an international multicenter TTM trial to better characterize current practice and clinically important outcomes. ## Methods A total 950 patients in the international TTM trial were randomly assigned to a TTM of 33 °C or 36 °C after resuscitation from cardiac arrest in 36 intensive care units. We recorded cumulative doses of sedative and analgesic drugs at 12, 24, and 48 h and normalized to midazolam and fentanyl equivalents. We compared number of medications used, dosing, and titration among centers by using multivariable models, including common severity of illness factors. We also compared dosing with time to awakening, incidence of clinical seizures, and survival. ## Results A total of 614 patients at 18 centers were analyzed. Propofol (70%) and fentanyl (51%) were most frequently used. The average dosages of midazolam and fentanyl equivalents were 0.13 (0.07, 0.22) mg/kg/h and 1.16 (0.49, 1.81) μg/k

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Author

Ameldina Ceric; Teresa L. May; Anna Lybeck; Tobias Cronberg; David B. Seder; Richard R. Riker; Christian Hassager; Jesper Kjaergaard; Zana Haxhija; Hans Friberg; Josef Dankiewicz; Niklas Nielsen

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)