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The article presents a novel corn-based fluorescent light-up biosensor designed for the label-free detection of long noncoding RNAs (lncRNAs) with an improved signal-to-background ratio. This biosensor utilizes duplex-specific nuclease-assisted target recycling amplification and transcription-driven synthesis of fluorogenic RNA aptamer-Corn, achieving a detection limit of 31.98 aM and the ability to quantify lncRNA at the single-cell level. The method allows for the differentiation of tumor cells from norma

Author

daniedanie2003

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EN