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Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines by Costa Conn; Ronald Shimmon; Frank Cordaro; Tracey-Lea Hargraves; Peter Ibrahim is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines about?
The structure-activity relationships for semicarbazide-sensitive amine oxidase (SSAO) inhibitors based on arylpropynylamines was investigated using solution-phase combinatorial Sonogashira coupling. The results suggest that binding to the active site occurs by coordination of the amine to the proximal copper(II) and formation of a p-complex between topaquinone and the electron-rich aryl group of the inhibitor.
Who reads Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Costa Conn; Ronald Shimmon; Frank Cordaro; Tracey-Lea Hargraves; Peter Ibrahim
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)
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