Can I read Polymorphisms in the Promoter of the Tumor Necrosis Factor-? Gene in Coal Miners on EtoBox?

Polymorphisms in the Promoter of the Tumor Necrosis Factor-? Gene in Coal Miners by Rihong Zhai; Manon Jetten; Roel P. F. Schins; Henk Franssen; Paul J. A. Borm is a Medicine article available to read on EtoBox.

What is Polymorphisms in the Promoter of the Tumor Necrosis Factor-? Gene in Coal Miners about?

Tumor necrosis factor-␣ (TNF) is recognized as a central mediator of mineral dust-induced lung fibrosis, and genetic polymorphisms of the TNF promoter have been reported to influence levels of TNF production. To assess whether polymorphisms within the TNF promoter gene are associated with susceptibility to coal workers' pneumoconiosis (CWP), the DNA of 78 coal miners was typed for G-to-A transitions at positions Ϫ238 and Ϫ308. Our results show that frequency of A Ϫ308 genotype (T2) is significantly overpresented in coal miners with CWP (50%), as compared with miners without CWP (25%) and controls (29%). After correction for cumulative dust exposure and smoking, the A Ϫ308 transition genotype is still associated with the presence of CWP (OR ϭ 3.0, 95%CI ϭ 1.0-9.0). Both A Ϫ238 and A Ϫ308 transition genotypes were related to TNF release from endotoxin-stimulated blood monocytes; only the A Ϫ238 transition and not the A Ϫ308 transition was associated to coal dust-induced TNF release. In summary, this study shows that the A Ϫ308 transition is related to CWP, but this relation is not paralleled by a different TNF release in this genotype. A larger number of patients coupled to frequent

Who reads Polymorphisms in the Promoter of the Tumor Necrosis Factor-? Gene in Coal Miners?

Author

Rihong Zhai; Manon Jetten; Roel P. F. Schins; Henk Franssen; Paul J. A. Borm

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0271-3586)

Published

1998

Language

EN

Field

Medicine (Health Sciences)