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Dopamine, a Co-regulatory Component, Bridges the Central Nervous System and the Immune System by Mingan Li; Lin Zhou; Xiaohui Sun; Yunqi Yang; Ce Zhang; Tian Wang; Fenghua Fu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dopamine, a Co-regulatory Component, Bridges the Central Nervous System and the Immune System about?

Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining physiological function in human body. In the past, most studies focused on the relationship between the dopaminergic system and neurological-related diseases. However, it has been found recently that DA is an immunomodulatory mediator and many immune cells express dopamine receptors (DRs). Some immune cells can synthesize and secrete DA and then participate in regulating immune function. DRs agonists or antagonists can improve the dysfunction of immune system through classical G protein signaling pathways or other non-receptor-dependent pathways. This article will discuss the relationship between the dopaminergic system and the immune system. It will also review the use of DRs agonists or antagonists to treat chronic and acute inflammatory diseases and corresponding immunomodulatory mechanisms.

Who reads Dopamine, a Co-regulatory Component, Bridges the Central Nervous System and the Immune System?

Author

Mingan Li; Lin Zhou; Xiaohui Sun; Yunqi Yang; Ce Zhang; Tian Wang; Fenghua Fu

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)