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Effect of Fractionated Regional External Beam Radiotherapy on Peripheral Blood Cell Count by B Zachariah; S.S Jacob; C Gwede; A Cantor; J Patil; L Casey; A.B Zachariah is a Medicine article available to read on EtoBox.

What is Effect of Fractionated Regional External Beam Radiotherapy on Peripheral Blood Cell Count about?

## Purpose: The purpose of this study was to assess the need for obtaining weekly complete blood count (cbc) values and to identify the pattern of changes in cbc during regional conventional fractionated radiotherapy. ## Methods and materials: A retrospective analysis of cbc data on 299 adult cancer patients who received definitive conventional radiotherapy to head and neck (n = 95), chest (n = 96), and pelvis (n = 108) was performed. temporal patterns and magnitude of change in white blood cells, neutrophils, lymphocytes, and platelets during radiotherapy were examined. ## Results: There were statistically significant declines in all counts, albeit not clinically significant. notable differences between disease sites were found. the greatest weekly interval change in counts occurred during the first week of radiotherapy for all groups of patients. the mean wbc nadir values during treatment were 5.8 for head & neck, 6.8 for chest, and 5.4 for pelvis. the nadirs for all counts occurred toward the middle-to-end of radiotherapy. lymphocytes were found to be more sensitive to radiotherapy than other leukocyte subcomponents. ## Conclusion: Our study suggests that weekly cbc monitoring i

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Author

B Zachariah; S.S Jacob; C Gwede; A Cantor; J Patil; L Casey; A.B Zachariah

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2001

Language

EN

Field

Medicine (Health Sciences)