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Strontium Incorporates at Sites Critical for Bone Mineralization in Rats with Renal Failure by Line Oste; Steven C. Verberckmoes; Geert J. Behets; Geert Dams; An R. Bervoets; Viviane O. Van Hoof; Sylvain Bohic; Michael Drakopoulos; Marc E. De Broe; Patrick C. D'Haese is a Physics and Astronomy article available to read on EtoBox.
What is Strontium Incorporates at Sites Critical for Bone Mineralization in Rats with Renal Failure about?
## Abstract We previously demonstrated the development of a mineralization defect during strontium administration and its reversibility after withdrawal in rats with chronic renal failure. Recently, strontium ranelate has been introduced as a therapeutic agent for osteoporosis. However, caution has to be taken, as this bone disorder mainly develops in elderly people who may present a moderately decreased renal function. In order to assess the ultra‐structural localization of strontium in bone and thereby to get a better insight into the element's systemic effects on bone, synchrotron‐based x‐ray micro‐fluorescence was applied, which showed that after 2 weeks of strontium loading (2 g l^−1^ in drinking water) in rats with renal failure, concomitant with the development of impaired mineralization, the element was localized mainly at the outer edge of the mineralized bone, while after longer loading periods, a more homogeneous distribution was found. After washout, strontium was found at sites deeper within the trabeculae, while newly deposited low‐strontium‐containing mineral was found at the outer edges. Synchrotron x‐ray micro‐diffraction analysis showed that strontium is incorpora
Who reads Strontium Incorporates at Sites Critical for Bone Mineralization in Rats with Renal Failure?
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- Author
- Line Oste; Steven C. Verberckmoes; Geert J. Behets; Geert Dams; An R. Bervoets; Viviane O. Van Hoof; Sylvain Bohic; Michael Drakopoulos; Marc E. De Broe; Patrick C. D'Haese
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0049-8246)
- Published
- 2006
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)