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Phenytoin requires careful therapeutic drug monitoring due to its narrow therapeutic index and non-linear kinetics, with adjustments based on clinical status rather than solely on concentration measurements. Toxicity can occur at elevated levels, and monitoring should include liver function tests and full blood counts, especially in patients with risk factors. Significant drug interactions can affect phenytoin levels and efficacy, necessitating consultation with a pharmacist for management.

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v855m5yn5k

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EN